What is a cardiac effect of meperidine?

• A. Increased myocardial contractility
• B. Decreased myocardial contractility
• C. Increase in heart rate
• D. No significant effect

Answer: (B)

Meperidine, an opioid analgesic, can have several effects on the cardiovascular system. One of the notable cardiac effects of meperidine is its potential to decrease myocardial contractility. This can occur through various mechanisms including its action on opioid receptors, which may lead to a negative inotropic effect. Additionally, meperidine can cause vasodilation and a decrease in systemic vascular resistance, potentially resulting in a lower cardiac output, which is associated with decreased contractility.

While meperidine can lead to various cardiovascular responses, its overall effect is often characterized by this depression of myocardial function rather than an increase in contractility or heart rate. Understanding the implications of meperidine's effects on the heart is essential, especially in patients who may have underlying cardiac conditions.